Contrast-enhanced MRI

3D PAUS (NO contrast agent administered)

3D PAUS close-up of region of interest. Angiogenesis present in region with highest SoS values.

PAM3+ Clinical Data

Technical Specifications of 3D PAUS whole-breast PAM3+ system:

  • Measurement time: ~ 6 minutes per breast (in total 6 laser wave lengths)
  • Isotropic voxel size as low as 0.008mm3 – incomparable even to world’s most advanced € 70 mln 11.7T MRI system
  • 390 mln voxels with 50,000 measuring positions and 12 mln signals

PAM3 Clinical Data

Technical Specification of 3D PAUS (near) whole-breast PAM3 system:

  • Measurement time: ~ 5 minutes per breast (in total 5 laser wave lengths)
  • 0.064mm3 voxels; 32 mln voxels, 50,000 measuring positions and 10 mln signals

Images above from left to right: PAM3+ 3D ultrasound (US) image with highest SoS region possibly indicating a malignity (red arrow);

subsequently region with highest SoS values  is segmented (green) within the 3D space; finally (most right image), complete 3D PA image is added to segmented region of interest (red arrow).

Blood vessels appear to have the highest density (within total 3D PA image) around this region of interest

PAM2 3D clinical data

Technical specifications of PAM2

  • 17,000 signals with 4,000 measuring points 60 million measurements
  • Image 50 million voxels
  • Measurement time 160 sec. per breast
  • 3D full breast imaging
  • No breast compression
  • Clinical characterisation study benign and malignant lesions
  • Impervious to tissue density, hence also suitable for younger women
  • Resolution 0.35mm

This 78 year old patient detected an abnormality in the left breast and was referred to the specialized breast clinic for further investigation in June 2018.

Histopathological investigation of the biopsy specimens revealed an intraductal papillary carcinoma, although atypical (BI-RADS VI).

PAM2 3D angiogenesis, confirmed by conventional X-ray/US and pathology for this 44 year old patient.

A scan of a 24 year-old healthy volunteer

A scan of a 49 year-old healthy volunteer